Graphene Oxide in Dentistry: A Review

Abstract   BACKGROUNackground and AimD & AIM: In this study, a brief but accurate evaluation of the role of graphene oxide in dentistry and interaction with all soft and hard tissues, the study of studies conducted in vitro or in vivo and new approaches in the field of tissue engineering has been investigated Material & Methods: Reviewed articles using Medline, Google scholar, Scopus, Science Citation Index and Magiran Embase databases and the keywords of graphene oxide, antibacterial material, tissue engineering and dentistry from 2015 to 2020 which includes 28 complete articles and 6 abstracts were gathered.  Results: The addition of graphene oxide to dental fillers or bone tissue regenerating membranes has provided acceptable results in many cases. In discussing mechanical properties, the addition of graphene oxide increases the mechanical strength and also improves the physical stability of the structure. Graphene and graphene based materials have shown toxic effects on hard and soft tissue cells, which are necessary for clinical applications, the optimal concentration of this oxide. Conclusion:  Adding graphene to dental materials was developed to increase their resistance to corrosion and improve their mechanical properties, but there was conflicting information about the cytotoxicity of graphene.